HLA-B*0811: another example of a single point substitution of the HLA-B*0801 allele

Authors
Magira, E Beznik-Cizman, B Monos, D
Citation
E. Magira et al., HLA-B*0811: another example of a single point substitution of the HLA-B*0801 allele, TISSUE ANTI, 56(5), 2000, pp. 457-459
Citations number
7
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
00012815 → ACNP
Volume
56
Issue
5
Year of publication
2000
Pages
457 - 459
Database
ISI
SICI code
0001-2815(200011)56:5<457:HAEOAS>2.0.ZU;2-E
Abstract
The described alle HLA-B*0811 is of Caucasoid origin. Most likely it derive d from a point mutation of the B*0801 allele at position 559, where an aden ine was converted to guanine. This position corresponds to codon 163 and re sulted in an amino acid change from threonine to alanine. This substitution may influence both, T-cell interactions and/or peptide binding.