Characterization of the novel allele HLA-B*4417: implications for bone marrow transplantation

Authors
Elsner, HA Schmitz, G Ballas, M Lenhard, V Blasczyk, R
Citation
Ha. Elsner et al., Characterization of the novel allele HLA-B*4417: implications for bone marrow transplantation, TISSUE ANTI, 56(5), 2000, pp. 463-466
Citations number
19
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
00012815 → ACNP
Volume
56
Issue
5
Year of publication
2000
Pages
463 - 466
Database
ISI
SICI code
0001-2815(200011)56:5<463:COTNAH>2.0.ZU;2-#
Abstract
The identification of the novel allele HLA-B*4417, which was found in a blo od donor of Caucasian origin, is described. In the sequence analysis the ne w allele differs from B*4402 by three nucleotides in exon 3. At the protein level, the new allele has two residue differences compared to B*4402. Due to substantial differences with other B*44 variants a possible mismatch may impair clinical outcome of bone marrow transplantation.