Sequence analysis of a new HLA-DR11 allele in a Caucasian Italian family: DRB1*11272

This communication describes a new DRB1*11 allele identified in a familial group of Caucasian individuals from central Italy. The new sequence has bee n officially named DRB1*11272 by the World Health Organization (WHO) Nomenc lature Committee (February 2000). It encodes an HLA antigen semologically r ecognized as DR11. The sequence variation of this new allele was localized to codon 77 of exon 2. It differs at position 230 from DRB1*11011 allele (A replacing C). and at position 231 from DRB1*1127 (C replacing T). At the a mino acid level, the DRB1*11272 mutation is silent with respect to the DRB* 1127 phenotype, coding for a synonymous asparagine.