Protection of cattle against rinderpest by intranasal immunisation with a dry powder tissue culture vaccine

Dry powder tissue culture rinderpest vaccine containing 10(2.5) TCID50 of v irus per dose administered intranasally to cattle induced high titre circul ating antibody responses and protection against challenge with a virulent s train of rinderpest virus. A reduction in the dose of virus to 10(1.1) TCID 50 resulted in a failure to elicit detectable antibody responses and a lack of protection. Intranasal powder vaccine offers several advantages over co nventional needle-administered aqueous rinderpest vaccine, including greate r stability in the absence of a cold chain, reduced risk of 'needle transfe r' of other microbial agents present in the vaccinated herd and lower cost. (C) 2000 Elsevier Science Ltd. All rights reserved.