The diagnosis of pheochromocytoma is challenging due to the variable presen
tations of patients affected with this neoplasm. This report describes four
dogs with pheochromocytoma in which radiography, ultrasonography and compu
ted tomography (CT) were key diagnostic tools. Computed tomography was the
most useful imaging modality for assessment of size, shape and margination
of the tumor. CT findings for the pheochromocytoma included a large, irregu
larly shaped mass in the dorsal midabdomen with multiple foci of low attenu
ation dispersed in hyperdense, highly vascular tissue. This neoplasm often
invades the caudal vena cava and other surrounding organs therefore, althou
gh a pheochromocytoma may be identified in the absence of clinical signs, i
t should not be considered an incidental lesion. The unpredictable growth r
ate and potential for invasion of major vessels warrants serious considerat
ion. Follow-up ultrasound and CT examinations are recommended for patients
with adrenal masses that do not undergo surgical excision.