J. Nauta et al., THE HAN-SPRD RAT IS NOT A GENETIC MODEL OF HUMAN AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY-DISEASE TYPE-1, Laboratory animals, 31(3), 1997, pp. 241-247
Human autosomal dominant polycystic kidney disease (ADPKD) is a high i
ncidence disorder, leading to renal failure in many patients. The majo
rity of cases results from a mutation in the PKD1 gene. The only well
documented animal model of ADPKD is the Han:SPRD-Pkd strain. Its genet
ic basis is unknown as yet. In the current study we determined whether
the disease in these rats is genetically linked to the rat homologue
of the PKD1 gene. We used the protamine gene as a polymorphic marker (
Prm1) of the PKD1 region. Matings of Han:SPRD-Pkd with BB rats and bac
kcross of the offspring with BE yielded animals informative for linkag
e analysis. This analysis revealed random segregation of the defect an
d the Prm1 marker, indicating that the model is not caused by a mutati
on in the PKD1 gene. We conclude that the Han:SPRD-Pkd rat strain is n
ot a genetic model of PKD1.