Monitoring inner ear pressure changes in normal guinea pigs induced by theMeniett (R) 20

The inner ear fluid pressure of guinea pigs was measured during a series of complex escalating middle ear pressure changes induced by the Meniett(R)20 (Pascal Medical, Sweden), a possible therapeutic pressure generator to be used by patients with Meniere's disease. Middle ear pressure changes were t ransferred instantly to the inner ear, although inner ear pressure declined while middle ear pressure stayed relatively stable. An average undershoot of - 1.0 cm H2O with respect to the steady-state pressure was seen after ap plication of a pressure pulse, which was released in a few seconds. The res ults did not fully comply with a simple linear model in which a constant fl ow resistance between the inner ear and cerebrospinal space was assumed.