Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy - a prospective, randomized, multi-centre study

Background: Comparative studies of omeprazole and lansoprazole are scarce a nd even scarcer are comparisons of higher doses. Most of the comparative st udies have assessed the effect of the two proton pump inhibitors (PPIs) on gastric acid secretion or gastric pH. Few studies have compared clinical en d-points such as oesophageal healing and symptom control. Aim: To determine the clinical efficacy of omeprazole 40 mg daily as compar ed to lansoprazole 30 mg twice a day in symptom control of patients with se vere symptomatic GERD. Methods: Ninety-six patients who failed a standard dose of lansoprazole (30 mg once daily), were enrolled in a prospective fashion from three VA medic al centres and were randomized to receive 6 weeks of either omeprazole 40 m g daily or lansoprazole 30 mg twice daily. Patients reported daily on sympt om severity and frequency, antacid consumption and side-effects. Results: Forty-six patients received omeprazole and 44 lansoprazole. Althou gh not statistically significant, there was a consistent trend of better sy mptom control in the omeprazole group for daytime and night-time heartburn and acid regurgitation. There was no statistical difference between the two groups in mean antacid consumption overall and at the end of each of the 6 weeks of the study. In addition, there was no significant difference in th e overall frequency of side-effects between the two groups nor for each ind ividual side-effect. Conclusion: Omeprazole 40 mg once daily is equally effective and tolerated as lansoprazole 30 mg twice daily in symptom control of patients with GERD.