Pf. Rosenbaum et al., Early child-care and preschool experiences and the risk of childhood acutelymphoblastic leukemia, AM J EPIDEM, 152(12), 2000, pp. 1136-1144
Citations number
66
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
An infectious etiology for childhood acute lymphoblastic leukemia (ALL) has
been suggested, yet few studies have focused on the role of early child ca
re. Day-care histories were examined in a case-control study of ALL in New
York State. Cases (n = 255) were diagnosed at one of four referral centers
between 1980 and 1991; controls (n = 760) were randomly selected from liveb
irths in the 31 counties served by the referral centers. Self-administered
questionnaires were mailed to the parents of cases and controls in 1995. Da
y-care histories were censored at the age of diagnosis for cases and at an
equivalent date for controls. The odds ratio for children who stayed at hom
e compared with those who attended day care for >36 months was 1.32 (95% co
nfidence interval (CI): 0.70, 2.52); the odds ratios for 1-18 and 19-36 mon
ths of day care were 1.74 (95% CI: 0.89, 3.42) and 1.32 (95% CI: 0.64, 2.71
), respectively. Elimination of cases with T-cell ALL enhanced the risk, St
arting care at an earlier age was not associated with a decreased risk of A
LL. These findings do not support the hypothesis that infrequent contact wi
th peers during early childhood could delay exposure to infectious diseases
and increase the risk of ALL.