M. Skacel et al., The diagnosis of low-grade dysplasia in Barrett's esophagus and its implications for disease progression, AM J GASTRO, 95(12), 2000, pp. 3383-3387
OBJECTIVE: The reported risk of progression from few-grade dysplasia (LGD)
to high-grade dysplasia (HGD) or carcinoma (CA) in Barrett's esophagus vari
es. However, the validity of a diagnosis of LGD may be questioned because o
f interobserver variability.
METHODS: A search of the Cleveland Clinic Foundation surgical pathology fil
es between 1986 and 1997 yielded biopsy specimens from 43 patients with Bar
rett's esophagus diagnosed and coded as LGD. Patients with concurrent or pr
ior diagnoses of HGD or carcinoma were excluded. The LGD cases were randomi
zed and blindly reviewed by three gastrointestinal (GI) pathologists along
with cases originally diagnosed as Barrett's esophagus without dysplasia (N
D; n = 28), indefinite for dysplasia (IND; n = 14), or HGD (n = 15). Each p
athologist classified every biopsy specimen as ND, IND, LGD, or HGD, and in
terobserver agreements were determined by kappa statistics (K). Follow-up d
ata were available on 25 patients originally diagnosed with LGD. Progressio
n was defined as a subsequent diagnosis of HGD or CA on esophageal biopsy o
r resection specimens.
RESULTS: Agreement between two GI pathologists for a diagnosis of LGD was f
air (K = 0.28) and poor (K = 0.21 and -0.04). Individual GI pathologists ag
reed with the original diagnosis of LGD in 70%, 56%, and 16% of cases. The
25 patients with follow-up included 21 men and four women (mean age, 67 yr)
with a mean follow-up of 26 months (range: 2-84 months). Seven patients (2
8%) with follow-up developed HGD (five patients) or CA (two patients), 2-43
months (median: 11 months) after a diagnosis of LGD. The individual GI pat
hologists' diagnosis did not correlate with progression. However, when at l
east two GI pathologists agreed on LCD, there was a significant association
with progression (seven of 17 patients, 41%, p = 0.04). When all three GI
pathologists agreed on a diagnosis of LGD, four of five patients progressed
(p = 0.012). In contrast, of the eight patients with follow-up and no agre
ement among GI pathologists for a diagnosis of LGD, none progressed.
CONCLUSIONS: A high degree of interobserver variability is seen in the hist
ological diagnosis of Barrett's esophagus-related LGD. Although the number
of observations is low, a consensus diagnosis of LGD among GI pathologists
suggests an increased risk of progression from LGD to HGD or carcinoma. (C)
2000 by Am. Cell. of Gastroenterology.