Isolated cervical recurrence of squamous cell carcinoma in the previously treated neck

Purpose: Our study goal was to identify clinical factors associated with, a nd that might predict, treatment outcome for patients with an isolated cerv ical recurrence of squamous cell carcinoma in the previously treated neck ( ICR-PTN). Materials and Methods: We reviewed all patients with noncutaneous head and neck squamous cell carcinoma treated at our tertiary care center between 19 87 and 1997, and identified 17 patients (2%) who later developed an isolate d recurrence in a previously treated neck. These patients made up our study group, and their charts were thoroughly reviewed. Outcome of salvage thera py (surgery, radiation, or combined therapy) for these patients was compare d with pooled clinicopathologic data using the Fisher exact test (one tail) . Results: Fifteen such ICR-PTN patients consented to salvage therapy. Six pa tients were without disease at last follow-up, and 3 were successfully pall iated. A statistically significant association between the side of ICR-PTN relative to the primary tumor and outcome of salvage therapy (P = .026) was noted, with ipsilateral neck recurrence being a favorable prognostic facto r. Trends that did not meet the standard for statistical significance were observed between a better outcome of salvage therapy and the following para meters: age of less than 60, nonsurgical initial treatment of the neck, and lack of a history of a recurrence before they developed the ICR-PTN. Conclusions: The current study showed that only the side of the ICR-PTN rel ative to the primary site is associated with outcome of salvage therapy. Ba sed on our findings and a review of the literature, we have developed a sum mary of factors that might predict which patients with an ICR-PTN are most likely to benefit from aggressive salvage therapy. Copyright (C) 2000 by W. B. Saunders Company.