Intracranial meningiomas are generally slow-growing neoplasms. Symptoms dep
end on their critical intracranial location. The authors describe a case of
rapidly enlarging meningioma that became symptomatic as a result of invasi
on by leukemic cells at the time of a blastic crisis in the context of chro
nic myeloid leukemia. infiltration of an intracranial meningioma by cells f
rom extracranial malignant neoplasms is a rare event. Even though central n
ervous system (CNS) or meningeal involvement is common in some hematologic
malignancies, this is, to the best of our knowledge, the first report of in
vasion of an intracranial meningioma by leukemic cells.