There are clinical situations in which even despite the use of simultaneous
multiple tissue expanders, complete coverage of a defect cannot be achieve
d. In this situation, serial, repeated tissue expansion may be indicated. T
here are few studies that have reported repeated tissue expansion in pediat
ric plastic surgery. Twelve children (6 girls, 6 boys) with a mean age of 7
years underwent serial tissue expansion for giant hairy nevus (N = 3) or b
urn reconstruction (N = 9). A total of 63 tissue expanders were used. Seria
l expansion of the expanded flap was performed a second time in 12 children
, a third time in 6 children, and a fourth time in 2 children. The major co
mplication rate was 4% for the first expansion, and 20%, 18%, and 0% for th
e second, third, and fourth expansions respectively. Clinically, at the tim
e of expander reinsertion, there was no evidence of capsule from the previo
us expander in any patient. This was confirmed on histological examination
of 12 biopsy specimens. Repeated tissue expansion is a safe and effective p
rocedure for use in pediatric plastic surgery.