Differences in DNA packaging genes and sensitivity to benzimidazole ribonucleosides between human cytomegalovirus strains AD169 and Towne

Authors
Krosky, PM Ptak, RG Underwood, MR Biron, KK Townsend, LB Drach, JC
Citation
Pm. Krosky et al., Differences in DNA packaging genes and sensitivity to benzimidazole ribonucleosides between human cytomegalovirus strains AD169 and Towne, ANTIVIR CHE, 11(5), 2000, pp. 349-352
Citations number
20
Categorie Soggetti
Microbiology
Journal title
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
ISSN journal
09563202 → ACNP
Volume
11
Issue
5
Year of publication
2000
Pages
349 - 352
Database
ISI
SICI code
0956-3202(200009)11:5<349:DIDPGA>2.0.ZU;2-Z
Abstract
The AD169 strain of human cytomegalovirus was approximately twofold more se nsitive to polyhalogenated benzimidazole ribonucleosides than Towne strain. Sequence differences between the two strains have been identified in genes UL51, UL52, UL56, UL77, UL89 and UL104. Because these genes are involved i n cleavage and packaging of viral DNA and the benzimidazole ribonucleosides inhibit this process, these sequence differences may be involved in the di fference in drug sensitivity.