A locus influencing total serum cholesterol on chromosome 19p - Results from an autosomal genomic scan of serum lipid concentrations in Pima Indians

A genome-wide linkage study was analyzed to identify loci that influence se rum lipid concentrations in Pima Indians, Linkage analyses were conducted f or total cholesterol measured in 998 siblings from 292 nuclear families, fo r total triglycerides in 547 siblings from 188 families, and for high densi ty lipoprotein (HDL) cholesterol in 590 siblings from 201 families. Genotyp es were generated for 516 autosomal microsatellite markers. Multipoint vari ance components methods were used to assess linkage. The strongest evidence for linkage with total cholesterol was on chromosome 19p (lod score 3.89), in the vicinity of the marker D19S1034, which is near the low density lipo protein receptor gene. The strongest evidence for linkage with HDL choleste rol was on chromosome 3q (lod score 2.64) near D3S3053, For triglycerides, the strongest evidence for linkage was on chromosome 2p near D2S1788 (lod s core 1.70) and on chromosome 3p near D3S2406 (lod score 1.77). This genomic scan provides evidence for a locus influencing total cholesterol concentra tion on chromosome 19p. It also suggests a locus influencing HDL cholestero l on chromosome 3q.