Regulation of the rat liver carnitine palmitoyltransferase I gene transcription by thyroid hormone

Authors
Barrero, MJ Marrero, PF Haro, D
Citation
Mj. Barrero et al., Regulation of the rat liver carnitine palmitoyltransferase I gene transcription by thyroid hormone, BIOC BIOP R, 279(1), 2000, pp. 81-88
Citations number
31
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
279
Issue
1
Year of publication
2000
Pages
81 - 88
Database
ISI
SICI code
0006-291X(200012)279:1<81:ROTRLC>2.0.ZU;2-J
Abstract
L-CPT I isotype is the main locus of control for liver LCFA oxidation. T3 l evels have been described as controlling L-CPT I gene expression, and in th is paper we demonstrate that rat liver CPT I promoter responds to T3. Using deleted reporter constructs we located the thyroid hormone-responsive elem ent between -2935 and -2918, consisting of a DR4. This response is mediated by the binding of the thyroid to this sequence as a monomer, homodimer, or heterodimer with RXR. (C) 2000 Academic Press.