Determination of the relative and absolute stereochemistry of a potent andalpha(1A)-selective adrenoceptor antagonist

Authors
Lagu, B Wetzel, JM Forray, C Patane, MA Bock, MG
Citation
B. Lagu et al., Determination of the relative and absolute stereochemistry of a potent andalpha(1A)-selective adrenoceptor antagonist, BIOORG MED, 10(24), 2000, pp. 2705-2707
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
24
Year of publication
2000
Pages
2705 - 2707
Database
ISI
SICI code
0960-894X(200012)10:24<2705:DOTRAA>2.0.ZU;2-6
Abstract
The binding affinities and selectivities of antagonists 1-4 for the alpha ( 1A)-adrenoceptor are dependent on the stereochemical orientation of the gro ups at the C-4 and C-5 positions of the oxazolidinone ring. The unambiguous assignment of the relative and absolute configurations of the diastereomer s of SNAP 7915 (1) is reported. (C) 2000 Elsevier Science Ltd. AII rights r eserved.