A novel pyridazinone derivative as a nonprostanoid PGI(2) agonist

Authors
Tsubaki, K Taniguchi, K Tabuchi, S Okitsu, O Hattori, K Seki, J Sakane, K Tanaka, H
Citation
K. Tsubaki et al., A novel pyridazinone derivative as a nonprostanoid PGI(2) agonist, BIOORG MED, 10(24), 2000, pp. 2787-2790
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
24
Year of publication
2000
Pages
2787 - 2790
Database
ISI
SICI code
0960-894X(200012)10:24<2787:ANPDAA>2.0.ZU;2-W
Abstract
A novel optically pure pyridazinone derivative was synthesized and identifi ed as a nonprostanoid PGI(2) agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 muM and has high oral bioava ilability (56%) with a long half-life (4.3 h) in rats. (C) 2000 Elsevier Sc ience Ltd. All rights reserved.