Synthesis and Class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines

Authors
Kanojia, RM Salata, JJ Kauffman, J
Citation
Rm. Kanojia et al., Synthesis and Class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines, BIOORG MED, 10(24), 2000, pp. 2819-2823
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
24
Year of publication
2000
Pages
2819 - 2823
Database
ISI
SICI code
0960-894X(200012)10:24<2819:SACITA>2.0.ZU;2-D
Abstract
The synthesis and in vitro Class III antiarrhythmic activity of several 4-a royl (and aryl)-1-aralkylpiperazine and piperidine derivatives are describe d. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC50 of 3 nM, ranks as one of the most potent (in vitro) compounds reported. (C) 2000 Elsevier Science Ltd. All rights reserved.