Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors

Authors
Zhang, N Wu, BQ Powell, D Wissner, A Floyd, MB Kovacs, ED Toral-Barza, L Kohler, C
Citation
N. Zhang et al., Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors, BIOORG MED, 10(24), 2000, pp. 2825-2828
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
24
Year of publication
2000
Pages
2825 - 2828
Database
ISI
SICI code
0960-894X(200012)10:24<2825:SASRO3>2.0.ZU;2-Y
Abstract
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy g roups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in t umor cells. (C) 2000 Elsevier Science Ltd. All rights reserved.