W. Atoyebi et al., Is it necessary to administer anti-D to prevent RhD immunization after thetransfusion of RhD-positive platelet concentrates?, BR J HAEM, 111(3), 2000, pp. 980-983
Serology for the presence of anti-D after RhD-incompatible platelet transfu
sions was performed in 24 RhD-negative patients with haematological disease
and 59 RhD-negative patients with non-haematological disease. None of the
patients were given prophylaxis with anti-D to prevent RhD immunization. Ei
ght out of 59 (13.5%) non-haematology patients developed detectable anti-D,
whereas 0 out of 24 (0%) of the haematology patients formed anti-D (P = 0.
06). The risk of alloimmunization after RhD-incompatible platelet transfusi
ons using platelet concentrates prepared by modern technical methods appear
s to be small in patients with haematological disease, but is significant i
n non-immunocompromised patients.