The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene

Authors
Mugneret, F Chaffanet, M Maynadie, M Guasch, G Favre, B Casasnovas, O Birnbaum, D Pebusque, MJ
Citation
F. Mugneret et al., The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene, BR J HAEM, 111(2), 2000, pp. 647-649
Citations number
7
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
111
Issue
2
Year of publication
2000
Pages
647 - 649
Database
ISI
SICI code
0007-1048(200011)111:2<647:T8MDTA>2.0.ZU;2-1
Abstract
Translocations affecting the chromosomal locus 8p12 are hallmarks of an aty pical stem cell myeloproliferative disorder. These events disrupt the fibro blast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus c atalytic domain with unrelated proteins. Here, we report on the characteriz ation of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.