Research progresses of artificial nucleic acid cleavage agents

Authors
Rong, W Gang, Z Jing, C Zhao, YF
Citation
W. Rong et al., Research progresses of artificial nucleic acid cleavage agents, CHIN SCI B, 45(22), 2000, pp. 2017-2028
Citations number
81
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
10016538 → ACNP
Volume
45
Issue
22
Year of publication
2000
Pages
2017 - 2028
Database
ISI
SICI code
1001-6538(200011)45:22<2017:RPOANA>2.0.ZU;2-M
Abstract
Artificial nucleic acid cleavage agents have attracted close attention beca use they play important roles in biochemistry and molecular biology. Accord ing to the cleavage mechanism of nucleic acid, they are divided into three types, namely free radical, phosphodiester bond hydrolysis and elimination cleavage agents. In this review, a series of cleavage agents, including the site- and sequence-specific ones, are illustrated, and some suggestions fo r the future researches in this field are also put forward.