Effect of acute phase response on cumulative troponin T release

We studied a possible effect of the extent of the acute phase response afte r acute myocardial infarction on the cumulative release of troponin T. The height of the acute phase response might influence the cumulative release o f troponin T, bound to the myofibrillar structures of the heart, in a diffe rent way compared to the free cytoplasmic cardiac marker hydroxybutyrate de hydrogenase (EC 1.1.1.27). To investigate this, the cumulative amount of C- reactive protein in plasma, i.e. the quantified acute phase response, was r elated to the cumulative plasma release of hydroxybutyrate dehydrogenase (a n established method for infarct sizing) on the one hand and to that of tro ponin T on the other hand. The study was performed in patients receiving (n=16) and in patients not re ceiving (n=6) thrombolytic therapy. Cumulative protein release was calculat ed using a two-compartment model for circulating proteins. Conclusions: The cumulative amount of plasma C-reactive protein is signific antly higher in the patients not receiving thrombolytic therapy, as is in a ccordance with earlier studies. The cumulative amount of troponin T release d is significantly related to the cumulated concentration of C-reactive pro tein, especially in patients not receiving thrombolytic therapy. The intens ity of the acute phase response, estimated from cumulative plasma C-reactiv e protein response, has no effect on the relative proportions of troponin T and hydroxybutyrate dehydrogenase released into plasma.