Dynamic resolution and stereoinversion of secondary alcohols by chemo-enzymatic processes

To overcome the maximum 50% yield limitation of classical resolution method s, deracemization processes involving a racemization step (dynamic resoluti on) or a prochiral intermediate (stereoinversion) have been developed. The use of transition metal complexes as racemizing agents, in combination with an enzymatic reaction, has been successfully extended to the deracemizaiio n of a number of simple or functionalized sec-alcohols. A two-enzyme proces s has been also investigated for their sequential or simultaneous deracemiz ation, Other prominent results arise from an (apparently general) oxidoredu ction process catalyzed by a single whole-cell microorganism.