Textbooks often assert that life began with specialized complex molecules,
such as RNA, that are capable of making their own copies. This scenario has
serious difficulties, but an alternative has remained elusive. Recent rese
arch and computer simulations have suggested that the first steps toward li
fe may not have involved biopolymers. Rather, noncovalent protocellular ass
emblies, generated by catalyzed recruitment of diverse amphiphilic and hydr
ophobic compounds, could have constituted the first systems capable of info
rmation storage, inheritance and selection. A complex chain of evolutionary
events, yet to be deciphered, could then have led to the common ancestors
of today's free-living cells, and to the appearance of DNA, RNA and protein
enzymes.