Multidrug resistance in gram-positive bacteria has become common worldwide.
In Japan until recently, gram-negative bacteria such as Pseudomonas aerugi
nosa, Klebsiella pneumoniae, and Serratia marcescens were controlled by car
bapenems, fluoroquinolones, and aminoglycosides. However, several of these
microorganisms have recently developed resistance against many antimicrobia
l drugs.