We report the emergence in Kenya during 1997-1999 of typhoid fever due to S
almonella enterica serovar Typhi resistant to ampicillin, tetracycline, ch[
oramphenicol, streptomycin, and cotrimoxazole. Genotyping by pulsed-field g
el electrophoresis of Xbal-digested chromosomal DNA yielded a single cluste
r. The multidrug-resistant S. Typhi were related to earlier drug-susceptibl
e isolates but were unrelated to multidrug-resistant isolates from Asia.