Modulation of endometrial transforming growth factor beta (TGF beta) by tamoxifen

Authors
Carmichael, PL Pole, JCM Neven, P
Citation
Pl. Carmichael et al., Modulation of endometrial transforming growth factor beta (TGF beta) by tamoxifen, EUR J CANC, 36, 2000, pp. S42-S43
Citations number
5
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
EUROPEAN JOURNAL OF CANCER
ISSN journal
09598049 → ACNP
Volume
36
Year of publication
2000
Supplement
4
Pages
S42 - S43
Database
ISI
SICI code
0959-8049(200009)36:<S42:MOETGF>2.0.ZU;2-T
Abstract
Transforming growth factor beta (TGF beta) immunoreactivity was determined in endometria from non-drug-therapy and tamoxifen-treated patients. Section s were scored for pathology and quantity image analysis performed to determ ine levels of glandular- or fibrosis-associated TGF beta1. Tamoxifen-treate d patients displayed greater levels of endometrial dysplasia and glandular hyperplasia, in addition to a statistically significant (P < 0.0001) elevat ion in gland-associated TGF<beta>1 protein. (C) 2000 Elsevier Science Ltd. All rights reserved.