Synthesis and antimicrobial activity of new adamantane derivatives II

A series of new derivatives of adamantane was synthesised. The new compound 4-(adamant-1-ylethylenoxycarbonyl)phthalanhydride obtained from 1-adamanta neethanol and trimellitic anhydride chloride, as well as 4-(adamant-1-ylmet hylenoxycarbonyl)phthalanhydride, appeared very useful for preparation of a number of N-substituted phthalimides. Antimicrobial activity of newly obta ined derivatives such as, for example, 4-(adamant-1-ylethylenoxycarbonyl)-N -(L-phenylalanyl)phthalimide or 4-(adamant-1-ylmethylenoxycarbonyl)-N-(L-le ucyl)-phtalimide was tested against Staphylococcus aureus, Bacillus sp., Mi crococcus flavus and Enterococcus faecium. The minimal inhibitory concentra tions for these compounds against Bacillus cereus were 15 and 8 mug/ml, res pectively. (C) 2000 Elsevier Science S.A. All rights reserved.