Production of alpha-2-macroglobulin preparations with desired properties.

Authors
Zorin, NA Zorina, RM Zorina, VN
Citation
Na. Zorin et al., Production of alpha-2-macroglobulin preparations with desired properties., GEMATOL TR, 45(5), 2000, pp. 20-21
Citations number
7
Categorie Soggetti
Hematology
Journal title
GEMATOLOGIYA I TRANSFUZIOLOGIYA
ISSN journal
02345730 → ACNP
Volume
45
Issue
5
Year of publication
2000
Pages
20 - 21
Database
ISI
SICI code
0234-5730(200009/10)45:5<20:POAPWD>2.0.ZU;2-K
Abstract
The authors describe a method of fast large-scale production of alpha-2-mac roglobulin (MG) from human plasma. The technique consists in combination of fractional precipitation by polyethylene glycol with anion exchange and me talchalate affinity chromatography. The MG preparations do not contain impu rity and output of the target product reach 40%. Methods of production of s table MG complexes with plasmin and alpha-interferon are detailed. Transfus iological prospects of the above preparations are discussed.