A PALLADIUM-CATALYZED ROUTE TO A BENZOFURAN ANALOG OF INDOLACTAM-V (ILV) - EFFECTS ON PKC ISOTYPE SELECTIVITY

Authors
KOZIKOWSKI AP MA DW DU LN LEWIN NE BLUMBERG PM
Citation
Ap. Kozikowski et al., A PALLADIUM-CATALYZED ROUTE TO A BENZOFURAN ANALOG OF INDOLACTAM-V (ILV) - EFFECTS ON PKC ISOTYPE SELECTIVITY, Pure and applied chemistry, 66(10-11), 1994, pp. 2087-2090
Citations number
32
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
66
Issue
10-11
Year of publication
1994
Pages
2087 - 2090
Database
ISI
SICI code
0033-4545(1994)66:10-11<2087:APRTAB>2.0.ZU;2-X
Abstract
A novel palladium catalyzed synthesis of the benzofuran analogue 11 of n-hexyl-ILV and details of its isoform selectivity are described. Of considerable interest is the unexpected finding that this subtle struc tural change leads to a compound that is more like phorbol 12,13-dibut yrate (PDBu) and less like n-octyl-ILV in its pattern of activity.