Prediction of ovulation by urinary hormone measurements with the home use ClearPlan (R) Fertility Monitor: comparison with transvaginal ultrasound scans and serum hormone measurements

The timing of sexual intercourse in relation to ovulation strongly influenc es the chance of conception. Daily serum LR measurements or transvaginal ul trasonography are not practical to determine ovulation in consecutive cycle s for an individual. A prospective study was initiated to test the home use performance of the ClearPlan(R) Fertility Monitor (CPFM) in ovulation pred iction compared with transvaginal ultrasonography and serum hormone measure ments. A total of 53 women aged 18-39 years with a normal uterus and at lea st one ovary, cycle length between 21-42 days and not using medication whic h interferes with ovarian function contributed 150 cycles for analysis. One cycle was anovulatory and no LH surge, indicating peak fertility, was dete cted by the monitor. Of the remaining 149 cycles, 135 (90.6%) had a monitor LB surge and ultrasonographically confirmed ovulation. Ovulation was detec ted in 91.1% of cycles during the 2 days of CPFM peak fertility, Ovulation was observed in 51.1% of cycles I day and in 43.2% of cycles 2 days after t he surge in serum LH, Ovulation never occurred before CPFM peak fertility o r the serum LH surge day. CPFM can help women who desire pregnancy to time intercourse. It may also have potential as a diagnostic aid and for monitor ing the treatment of infertility.