The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

Authors
Lanier, LL Bakker, ABH
Citation
Ll. Lanier et Abh. Bakker, The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function, IMMUNOL TOD, 21(12), 2000, pp. 611-614
Citations number
32
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
12
Year of publication
2000
Pages
611 - 614
Database
ISI
SICI code
0167-5699(200012)21:12<611:TITADI>2.0.ZU;2-#
Abstract
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covale ntly with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathwa ys. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of h ematopoietic cells. However, DAP12(-/-) humans develop presenile dementia a nd bone cysts, and DAP12(-/-) mice show impaired immune responses.