Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay

Authors
Burrill, W Barber, JBP Roberts, SA Bulman, B Scott, D
Citation
W. Burrill et al., Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay, INT J RAD B, 76(12), 2000, pp. 1617-1619
Citations number
13
Categorie Soggetti
Experimental Biology
Journal title
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
ISSN journal
09553002 → ACNP
Volume
76
Issue
12
Year of publication
2000
Pages
1617 - 1619
Database
ISI
SICI code
0955-3002(200012)76:12<1617:HOCRIB>2.0.ZU;2-6
Abstract
Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radia tion-induced chromosome damage (micronucleus induction) compared with 10% o f healthy controls. Twenty-two first-degree relatives of 11 sensitive patie nts had an average micronucleus yield significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inher ited characteristic associated with predisposition to breast cancer.