SYNTHESES, CHARACTERIZATION AND ANTIINFLAMMATORY ACTIVITY OF A BENZAMIDE DERIVATIVE AND ITS METAL-CHELATES

N-Phenylbenzamide-2,2'-dicarboxylic acid (PBDA) and its copper(II), ni ckel(II), cobalt (II), zinc(II) and manganese(II) chelates have been s ynthesized and characterized by their physical measurements, infrared and electronic spectra and magnetic moment data, In an acute anti-infl ammatory test, the cobalt chelate was most active (31.1% inhibition) f ollowed by the zinc and copper chelates, whereas the copper chelate (2 2.3% inhibition) was most active in an adjuvant arthritis test, Again the cobalt chelate was most active in the cotton-wad granuloma test, G astric irritancy was markedly reduced after chelation by copper, follo wed in order by zinc, cobalt, manganese and nickel chelates. (C) 1997 by John Whey & Sons, Ltd.