Fluorinated imidazoles as F-19 probes for biomimetic studies of heme a(3) - Cu-b site in cytochrome c oxidase

A series of 4,5-imidazole carboxylic acids bearing fluorinated substituents is synthesized from simple commercially available fluorinated substrates u tilizing several different approaches to modify the imidazole core. These i midazole derivatives are specifically designed to be sensitive probes for p hysicochemical studies of processes in the coordination environments of met als employing F-19-NMR techniques, particularly in the context of our ongoi ng biomimetic work on imidazole-derivatized porphyrins. (C) 2000 Elsevier S cience S.A. All rights reserved.