In this Letter we announce rigorous results that elucidate the relation bet
ween metastable states and low-lying eigenvalues in Markov chains in a much
more general setting and with considerably greater precision than has so f
ar been available. This includes a sharp uncertainty principle relating all
low-lying eigenvalues to mean times of metastable transitions, a relation
between the support of eigenfunctions and the attractor of a metastable sta
te and sharp estimates of the convergence of the probability distribution o
f the metastable transition times to the exponential distribution.