Cells in sol-gels I: A cytocompatible route for the production of macroporous silica gels

A novel, high hydrolysis ratio sol-gel route for the biocompatible producti on of macroporous silica gels is presented. This route exploits the two ste p nature of the gelation reaction to remove undesired alcohol by-products f rom an acidic aqueous sol prior to gelation. These alcohol-free sols will g el when the pH is raised to the physiologic range in a two-step, acid/base catalyzed process. Furthermore, monolithic macroporous samples can be produ ced in a controlled manner by introducing water-soluble organic polymers in to the sol.