BIOACTIVE COMPONENTS FROM FICUS-GLOMERATA

Different parts of the plant Ficus glomerata Roxob was extracted with water and organic solvents. The effects of these extracts on blood sug ar level of streptozotocin induced diabetic rats were studied. The pet ether extract of the stem bark of the plant reduced the blood sugar l evel significantly. Extracts from fruit and latex of the plant did not have any significantly effect on blood sugar level of these diabetic rats. The pet ether extract of the stem bark completely inhibited the enzymes glucose-6-phosphatase and arginase and activated the enzyme gl ucose-6-phosphate dehydrogenase from rat liver. Extracts from fruit an d latex inhibited only glucose-6-phosphatase but not arginase from rat liver. A number of components from pet ether extract of the stem bark were isolated and purified. The effect of these purified components o n pure enzyme glucose-6-phosphate dehydrogenase were investigated. The chemical characterisation of some of these components were carried ou t.