Lamotrigine overdose in an adult

Background: Lamotrigine is an antiepileptic agent that has been shown to be an effective adjunctive treatment for refractory partial and generalized s eizures, it is now licensed in more than 70 countries for this indication, There is very little published material about the effects of acute overdose with lamotrigine. Case Report: We describe the findings in a patient follo wing the deliberate ingestion of a large amount of lamotrigine (stated 4.5 g, absorbed estimated 2.9 g), in excess of that previously described in the literature. The main clinical features were ataxia and rotary nystagmus, E lectrocardiogram was unremarkable. Peak measured concentration of lamotrigi ne was 35.8 mg/L and half-life 19.5 hours, suggesting linear kinetics in ov erdose.