Background: Lamotrigine is an antiepileptic agent that has been shown to be
an effective adjunctive treatment for refractory partial and generalized s
eizures, it is now licensed in more than 70 countries for this indication,
There is very little published material about the effects of acute overdose
with lamotrigine. Case Report: We describe the findings in a patient follo
wing the deliberate ingestion of a large amount of lamotrigine (stated 4.5
g, absorbed estimated 2.9 g), in excess of that previously described in the
literature. The main clinical features were ataxia and rotary nystagmus, E
lectrocardiogram was unremarkable. Peak measured concentration of lamotrigi
ne was 35.8 mg/L and half-life 19.5 hours, suggesting linear kinetics in ov
erdose.