Involvement of platelet activating factor in the endotoxin-induced effectson gastrointestinal electrical activity and some haematological parametersin the conscious miniature pig

In conscious miniature pigs the influence of intravenous dose of lipopolysa ccharide (LPS), 10 mug/kg over 10 min, with and without pretreatment with a platelet activating factor (PAF) antagonist, SAH 63-675 10 mg/kg, on gastr ointestinal electrical activity, arterial pressure and clinical and haemato logical parameters was studied. Dose of LPS provoked mild clinical signs an d hypotension, which were prevented by PAF antagonism. The LPS induced leuk ocytosis and increase in mature neutrophils, however, were PAF independent. Pretreatment with the PAF antagonist attenuated the LPS-provoked inhibitio n of electrical activity in the antrum, jejunum, ileum and caecum. These re sults suggest a beneficial effect of PAF antagonism in porcine endotoxaemia .