Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek's disease virus

Microarrays containing 1,126 nonredundant cDNAs selected from a chicken act ivated T-cell expressed sequence tag database (http://chickest.udel.edu) we re used to examine changes in host cell gene expression that accompany infe ction of chicken embryo fibroblasts (CEF) with Marek's disease virus (MDV). Host genes that were reproducibly induced by infection of CEF with the onc ogenic RB1B strain of MDV included macrophage inflammatory protein, interfe ron response factor 1, interferon-inducible protein, quiescence-specific pr otein, thymic shared antigen 1, major histocompatibility complex (MHC) clas s I, MHC class II, beta (2)-microglobulin, clusterin, interleukin-13 recept or alpha chain, ovotransferrin, a serine/threonine kinase, and avian leukos is virus subgroup J glycoprotein.