Direct ex vivo measurement of CD8(+) T-lymphocyte responses to human parvovirus B19

Authors
Tolfvenstam, T Oxenius, A Price, DA Shacklett, BL Spiegel, HML Hedman, K Norbeck, O Levi, M Olsen, K Kantzanou, M Nixon, DF Broliden, K Klenerman, P
Citation
T. Tolfvenstam et al., Direct ex vivo measurement of CD8(+) T-lymphocyte responses to human parvovirus B19, J VIROLOGY, 75(1), 2001, pp. 540-543
Citations number
34
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
1
Year of publication
2001
Pages
540 - 543
Database
ISI
SICI code
0022-538X(200101)75:1<540:DEVMOC>2.0.ZU;2-E
Abstract
Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parv ovirus B19-derived CD8(+) T-lymphocyte epitope is described. This HLA-B35-r estricted peptide derives from the nonstructural (NS1) protein and is stron gly immunogenic in B19 virus-seropositive donors.