Dr. Drake et al., Induction of polyomavirus-specific CD8(+) T lymphocytes by distinct dendritic cell subpopulations, J VIROLOGY, 75(1), 2001, pp. 544-547
Dendritic cells are pivotal antigen-presenting cells for generating adaptiv
e T cell responses. Here, we show that dendritic cells belonging to either
the myeloid-related or lymphoid-related subset are permissive for infection
by mouse polyomavirus and, when loaded with a peptide corresponding to the
immunodominant anti-polyomavirus CD8(+) T-cell epitope or infected by poly
omavirus, are each capable of driving expansion of primary polyomavirus-spe
cific CD8(+) T-cell responses in vivo.