Methadone, ciprofloxacin, and adverse drug reactions

Authors
Herrlin, K Segerdahl, M Gustafsson, LL Kalso, E
Citation
K. Herrlin et al., Methadone, ciprofloxacin, and adverse drug reactions, LANCET, 356(9247), 2000, pp. 2069-2070
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
356
Issue
9247
Year of publication
2000
Pages
2069 - 2070
Database
ISI
SICI code
0140-6736(200012)356:9247<2069:MCAADR>2.0.ZU;2-0
Abstract
Ciprofloxacin, given to a patient successfully treated with methadone for m ore than 6 years, caused profound sedation, confusion, and respiratory depr ession. We suggest that this was caused by ciprofloxacin inhibition of CYP1 A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.