Perspectives on metabolic suppression during mammalian hibernation and daily torpor

During hibernation and daily torpor, metabolic rate (MR) can be maximally r educed to only 1 or 12%, respectively, of the minimum euthermic levels. The physiological mechanisms causing these metabolic reductions remain unclear and are under debate. Earlier observations based on high ratio of (MReuthe rmia/MRhibernation) and high corresponding Q(10) values (>3), suggest tempe rature-independent mechanisms such as tissue acidification through retentio n of respiratory CO2 may be involved in actively inhibiting metabolism beyo nd the effect of low body temperature (Tb) alone. This, however, has been c hallenged due to inherent problems in defining the proper MReuthermia For c omparison and the proper execution of Q(10) calculation. The proposition th at a reduced thermoconductance during torpor could account for the reduced metabolism and that the (Tb-Ta) gradient ultimately determines the level of metabolism during torpor have also been challenged. Since the thermoregula tory set-point (Tset) is progressively lowered during entry into torpor and remains low during torpor, and hibernators and daily heterotherms are capa ble of strong thermogenic efforts even at low Tb the prevailing level of MR during torpor likely reflects the thermogenic magnitude (or its suppressio n) of the error signal (Thypo-Tset) and the Arrhenius effect on MR. To date , however, no direct evidence hits been provided to argue Fur or against an y of the above conjectures. We have proposed a different experimental appro ach which could allow direct comparison of minimum MR at the same Tb during hibernation and induced hypothermia. This hopefully will resolve if active inhibition of MR is indeed a state-dependent characteristic of torpor and hibernation.