AFRAMODIAL AND OTHER BIOACTIVE DITERPENOIDS FROM AFRAMOMUM SPECIES

Authors
AYAFOR JF TCHUENDEM MHK NYASSE B TILLEQUIN F ANKE H
Citation
Jf. Ayafor et al., AFRAMODIAL AND OTHER BIOACTIVE DITERPENOIDS FROM AFRAMOMUM SPECIES, Pure and applied chemistry, 66(10-11), 1994, pp. 2327-2330
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
66
Issue
10-11
Year of publication
1994
Pages
2327 - 2330
Database
ISI
SICI code
0033-4545(1994)66:10-11<2327:AAOBDF>2.0.ZU;2-O
Abstract
The biological activity of the potential therapeutic agent, 8beta, 17- epoxy-12E-labdene-15,16-dial (aframodial) 1, has been briefly reviewed . Ten other Cameroonian Aframomum species have been investigated as po tentially improved sources for 1 and their aframodial content analyzed . In the course of these investigations three novel diterpenoids, aula cocarpinolide, aulacocarpin A, and aulacocarpin B, were isolated from A. aulacocarpos and their structures determined as 2, 3. and 4, respec tively. In the structural elucidation, particular use was made of high -field 1D 2D and 3D NMR spectroscopic techniques.