Dexamethasone treated rats inoculated with Trypanosoma cruzi developed acut
e parasitemia. In addition, these animals concomitantly developed severe Pn
eumocystis carinii pneumonia (PCP) and died after 4 weeks of immunosuppress
ion (100%). However, immunocompetent (untreated) rats inoculated with T. cr
uzi did not acquire P. carinii and recovered from T. cruzi infection. Rats
immunosuppressed, but not inoculated with T. cruzi, developed only PCP and
died 5-6 weeks later (93%). In contrast, immunocompetent or immunocompromiz
ed IRC mice infected with T. cruzi all died of acute parasitemia in only 8-
12 days with no detectable PCP infection. In conclusion, rats immunosuppres
sed and T. cruzi inoculated can serve as a MOPPS model for a single drug ev
aluation. In addition, T. cruzi infection independently does not provoke P.
carinii pneumonia in this model. Finally, patients with Chagas' disease tr
eated with corticosteroids may be at risk for PCP and should be considered
for chemoprophylaxis. (C) 2000 Academic Press.