MEDULLARY THICK LIMB BASOLATERAL CL- CHANNELS

Authors
REEVES WB WINTERS CJ ZIMNIAK L ANDREOLI TE
Citation
Wb. Reeves et al., MEDULLARY THICK LIMB BASOLATERAL CL- CHANNELS, Wiener Klinische Wochenschrift, 109(12-13), 1997, pp. 465-470
Citations number
40
Categorie Soggetti
Medicine, General & Internal
Journal title
Wiener Klinische Wochenschrift → ACNP
ISSN journal
00435325
Volume
109
Issue
12-13
Year of publication
1997
Pages
465 - 470
Database
ISI
SICI code
0043-5325(1997)109:12-13<465:MTLBCC>2.0.ZU;2-B
Abstract
Chloride transport by the medullary thick ascending limb is a major de terminant of urinary concentrating and diluting power and also of tubu loglomerular feedback. In this review, we discuss the electrophysiolog ic, regulatory, and molecular features of a Cl- channel present in bas olateral membranes from the medullary thick ascending limb. Functional and immunohistochemical data support the view that rbCIC-Ka, a CIC Cl - channel cloned from rabbit kidney medulla, may be the Cl- channel wh ich mediates basolateral Cl- efflux.